热带生物源农药创制及应用-孙然锋

团队名称：海南大学热带生物源农药创制及应用团队

所属协同创新中心：南繁与热带高效农业协同创新中心

团队负责人：

孙然锋，海南大学热带农林学院副院长，热带农林生物灾害绿色防控教育部重点实验室副主任，中国植物保护学会化感专业委员会委员，海南省植物保护学会理事，海南大学C类高层次人才，入选“南海名家”青年项目。近5年主持国家自然科学基金2项，海南省烟草局科技计划项目1项等。在绿色农药创制方面具有突出专长和丰富经验，并取得显著成绩，发现高活性杀虫杀菌化合物10余个，其中高效低毒化合物叔肟虫脲已转让江苏蓝丰生物化学有限公司进行登记。针对苯甲酰脲类昆虫生长调节剂开展系统构效关系研究，提出苯甲酰脲与害虫的作用靶点为双作用位点的观点，得到国内外同行的认可，并受邀在农药学顶级期刊《Journal of Agricultural and Food Chemistry》（2015, 63, 31, 6847-6865）撰写了苯甲酰脲类几丁质合成抑制剂发展40年的综述文章。先后在《Journal of Agricultural and Food Chemistry》《Industrial Crops and Products》《Pest Management Science》等国际知名期刊发表SCI论文30余篇，申请中国发明专利9项，已授权4项。目前发现广谱热带植物源杀菌剂1个，其杀菌谱和杀菌活性活性优于商品化植物源杀菌剂（蛇床子素、丁香酚、香芹酚），已获授权中国专利，有望开发为新型植物源杀菌剂；发现热带植物源杀线虫植物4种，基于“来自自然再回归自然”的生态防控理念，开发杀线虫植物有机肥1种，田间药效试验证明该有机肥可明显降低土壤中根结线虫对黄瓜和雪茄烟的侵染，并保持土壤中自由线虫的生态多样性。

团队研究方向：

1．热带植物源农药先导发现及结构优化；

2．绿色化学农药设计及合成；

3．根结线虫与植物互作信息物质的结构鉴定及生态学功能研究；

4．根结线虫绿色防控技术研究。

团队成员：

1. 李栋，副教授

2. 胡展，讲师

3. 谢佳，讲师

4. 王帅，讲师

团队代表性成果：

代表性论文：

1. Zhang, Xi; Hu, Zhan; Wang, Shuai; Yin, Fengman; Wei, Yuyang; Xie, Jia; Sun, Ranfeng*, Discovery of 2-Naphthol from the Leaves of Actephila merrilliana as a Natural Nematicide Candidate. Journal of Agricultural and Food Chemistry 2023, 71 (36), 13209-13219.

2. Li, Dong; Zhou, Chunran; Wang, Shuai; Hu, Zhan; Xie, Jia; Pan, Canping*; Sun, Ranfeng*, Imidacloprid-induced stress affects the growth of pepper plants by disrupting rhizosphere-plant microbial and metabolite composition. Science of The Total Environment 2023, 898, 165395.

3. He, Jianguo; Dou, Menglan; Xie, Jia; Hou, Shuai; Liu, Qifeng; Hu, Zhan; Zhang, Beijing; Zheng, Shuai; Yin, Fengman; Zhang, Meng; Xie, Changping; Lu, Dadong; Ding, Xiaofan; Zhu, Chaohua; Sun, Ranfeng*, Discovery of zeylenone from Uvaria grandiflora as a potential botanical fungicide. Pest Management Science 2021, 77 (12), 5407-5417.

4. Yin, Fengman; Liu, Qifeng; Zhang, Beijing; Zhang, Xi; He, Jianguo; Xie, Jia; Hu, Zhan; Sun, Ranfeng*, Microemulsion preparation of Waltheria indica extracts and preliminary antifungal mechanism exploration. Industrial Crops and Products 2021, 172, 114000.

5. Zhang, Meng; Dou, Menglan; Xia, Yingying; Hu, Zhan; Zhang, Beijing; Bai, Yongxia; Xie, Jia; Liu, Qifeng; Xie, Changping; Lu, Dadong; Hou, Shuai; He, Jianguo; Tao, Jun; Sun, Ranfeng*, Photostable 1-Trifluoromethyl Cinnamyl Alcohol Derivatives Designed as Potential Fungicides and Bactericides. Journal of Agricultural and Food Chemistry 2021, 69 (19), 5435-5445.

6. Yu, Xiuqiang^†; Zhu, Xinyue^†; Zhou, Yang; Li, Qinglin; Hu, Zhan; Sun, Ranfeng*, et al. Discovery of N-Aryl-pyridine-4-ones as Novel Potential Agrochemical Fungicides and Bactericides. Journal of Agricultural and Food Chemistry, 2019, 67(50): 13904-13913.

7. Liang, Cai; Yang, Li; Shao, Yu; Zhu, Xinyue; Sun, Ranfeng*, et al. Broad-spectrum antifungal activity of dichloromethane extract of Waltheria indica stems and isolated compounds. Industrial Crops and Products. 2019, 142: 111855.

8. Zhao, Qiqi; Sun, Ranfeng*; Liu, Yuxiu; Chen, Peiqi; Li, Yongqiang; Yang, Shaoxiang; Wang, Qingmin*. Synthesis and insecticidal activity studies of novel phenylpyrazole derivatives containing arylimine or carbimidate moiety. Bioorganic & Medicinal Chemistry, 2019, 27(21):115092.

9. Song, Xiangmin; Zhu, Xinyue; Li, Ting; Liang, Cai; Zhang, Meng; Shao, Yu; Tao, Jun; Sun, Ranfeng*. Dehydrozingerone Inspired Discovery of Potential Broad-Spectrum Fungicidal Agents as Ergosterol Biosynthesis Inhibitors. Journal of Agricultural and Food Chemistry, 2019, 67(41): 11354-11363.

10. Chen Peiqi; Song Xiangmin; Fan Yongmei; Kong Weihao, Zhang Hao, Sun Ranfeng*. Investigation of Novel Pesticides with Insecticidal and Antifungal Activities: Design, Synthesis and SAR Studies of Benzoylpyrimidinylurea Derivatives. Molecules, 2018, 23(9): 2203.

11. Song Xiangmin, Liu Chunjuan, Chen Peiqi, Zhang Hao, Sun Ranfeng*. Natural product-based pesticide discovery: design, synthesis and bioactivity studies of N-amino-maleimide derivatives. Molecules, 2018, 23(7): 1521.

12. Chen Peiqi, Liu Chunjuan, Hu Jianfeng, Zhang Hao, Sun Ranfeng*. Design, Synthesis and fungicidal activity studies of 3-ferrocenyl-N-acryloylmorpholine. Journal of Organometallic Chemistry, 2018, 854(1): 113-121.

13. Sun Ranfeng*, Liu Chunjuan, Zhang Hao, Wang Qingmin*. Benzoylurea chitin synthesis inhibitors. Journal of Agricultural and Food Chemistry, 2015, 63(31): 6847-6865.

14. Sun Ranfeng, Wang Huangdong, Hu Jianfeng, Zhao Jiudong, Zhang Hao*. Pyridine-phosphinimine ligand-accelerated Cu(I)-catalyzed azide-alkyne cycloaddition for preparation of 1-(pyridin-2-yl)-1,2,3-triazole derivatives. Organic & Biomolecular Chemistry, 2014, 12(31): 5954-5963.

15. Sun Ranfeng, Wang Ziwen, Li Yongqiang, Xiong Lixia, Liu Yuxiu, Wang Qingmin*. Design, synthesis, and insecticidal evaluation of new benzoylureas containing amide and sulfonate groups based on the sulfonylurea receptor protein binding site for diflubenzuron and glibenclamide. Journal of Agricultural and Food Chemistry, 2013, 61(3): 517-522.

16. Sun Ranfeng, Li Yongqiang, Xiong Lixia, Liu Yuxiu, Wang Qingmin*. Design, synthesis, and insecticidal evaluation of new benzoylureas containing isoxazoline and isoxazole group. Journal of Agricultural and Food Chemistry, 2011, 59(9): 4851-4859.

17. Sun Ranfeng, Liu Yuxiu, Zhang Yonglin, Xiong Lixia, Wang Qingmin*. Design and synthesis of benzoylphenylureas with fluorinated substituents on the aniline ring as insect growth regulators. Journal of Agricultural and Food Chemistry, 2011, 59(6): 2471-2477.

18. Sun Ranfeng, Li Yongqiang, Lü Maoyun, Xiong Lixia, Wang Qingmin*. Synthesis, larvicidal activity, and SAR studies of new benzoylphenylureas containing oxime ether and oxime ester group. Bioorganic & Medicinal Chemistry Letters, 2010, 20(15): 4693-4699.

19. Sun Ranfeng, Zhang Yonglin, Chen Li, Li Yongqiang, Li Qingshan, Song Haibin, Huang Runqiu, Bi Fuchun, Wang Qingmin*. Design, synthesis, and insecticidal activities of new N-benzoyl-N′-phenyl-N′-sulfenylureas. Journal of Agricultural and Food Chemistry, 2009, 57, 3661-3668.

20. Sun Ranfeng, Zhang Yonglin, Bi Fuchun, Wang Qingmin*. Design, synthesis, and bioactivity study of novel benzoylpyridazyl ureas. Journal of Agricultural and Food Chemistry, 2009, 57(9): 6356–6361.

21. Sun Ranfeng, Lü Maoyun, Chen Li, Li Qingshan, Song Haibin, Bi Fuchun, Huang Runqiu, Wang Qingmin*. Design, synthesis, bioactivity, and structure-activity relationship (SAR) studies of novel benzoylphenylureas containing oxime ether group. Journal of Agricultural and Food Chemistry, 2008, 56(23): 11376–11391.

获奖及荣誉称号：

1. 2022年，海南省“优秀研究生导师”

2. 2020年，荣获“南海名家青年项目”

3. 2020年，荣获“海南省领军人才”

4. 2012年，“天津市优秀博士论文”获得者；

5. 2012年，“全国优秀博士论文提名论文”获得者；

6. 2010年，荣获“南开大学优秀毕业研究生”称号

团队合影：