热带饲料添加剂创新团队-陈云

团队名称：海南大学热带饲料添加剂创新团队

所属中心：南繁与热带高效农业协同创新中心

团队负责人：陈云，博士，副教授，博士研究生导师。长期从事南药的营养与免疫研究，主持国家自然科学基金项目2项、海南省重点研发计划项目2项、海南省自然科学基金项目2项。以第一/通讯作者身份在Carbohydrate polymers、International Journal of Biological Macromolecules等杂志上累计发表了27篇论文，其中SCI论文25篇。出版著作2部，获得授权发明专利2项。

团队研究方向：营养与免疫调控

团队研究成果：

1. Haowen Wu , Qiyuan Luo , Yijing Chen , Suya Liao , Huricha Chen , Yun Chen*, Yao Qin. Inhibiting mechanism of Alpiniae oxyphyllae fructus polysaccharide 3 against the replication of porcine epidemic diarrhea virus [J]. Virology, 2023, 587, 109848.

2. Chenglong Zhang, Jiaguo Liu, Zengyang Xing, Yun Chen*, Huricha Chen, Yongjian Zhu, Haowen Wu. PLGA nanoparticle with Amomum longiligulare polysaccharide 1 increased the immunogenicity of infectious bursal disease virus VP2 protein [J]. British Poultry Science, 2023, 64, 176-184.

3. Suya Liao, Yijing Chen, Yulan Yang, Guanhua Wang, Qihang Wang, Jiaxin Liu, Haowen Wu, Qiyuan Luo, Yun Chen*. Detection of RNA-dependent RNA polymerase of porcine epidemic diarrhea virus [J]. Journal of Immunological Methods, 2023, 515, 113442.

4. Haowen Wu, Huricha Chen, Jiaguo Liu, Zengyang Xing, Jiahao Ni, Ling Teng, Yun Chen*. Amomum longiligulare polysaccharide 1- PLGA nanoparticle promotes the immune activities of T lymphocytes and dendritic cells [J]. International Immunopharmacology, 2022 112, 109204.

5. Qiyuan Luo, Chenglong Zhang, Yun Chen*, Huricha Chen*, Yuhui Yang. Alpiniae oxyphyllae fructus polysaccharide 3 inhibits porcine epidemic diarrhea virus entry into IPEC-J2 cells [J]. Research in Veterinary Science, 2022, 152, 434–441.

6. Jiahao Ni, Huricha Chen, Chenglong Zhang, Qiyuan Luo, Yao Qin, Yuhui Yang, Yun Chen*. Characterization of Alpinia officinarum Hance polysaccharide and its immune modulatory activity in mice [J]. Food & Function, 2022, 13, 2228-2237.

7. Yongjian Zhu, Xiru Wang, Chenglong Zhang, Jiahao Ni, Qiyuan Luo, Ling Teng, Suya Liao, Yuhui Yang, Huricha Chen, Yun Chen*. Characterizations of glucose-rich polysaccharides from Amomum longiligulare T.L.Wu fruits and their effects on immunogenicities of infectious bursal disease virus VP2 protein [J]. International Journal of Biological Macromolecules, 2021, 183, 1574-1584.

8. Yun Chen*, Yu Zhang, Qiyuan Luo, Yongjian Zhu, Huijun Du, Suya Liao, Yuhui Yang, Huricha Chen. Inhibition of porcine epidemic diarrhea virus by Alpiniae oxyphyllae fructus polysaccharide 3 [J]. Research in Veterinary Science, 2021, 141, 146-155.

9. Ruigang Zhou, Ling Teng, Yongjian Zhu, Chenglong Zhang, Yuhui Yang, Yun Chen*. Preparation of Amomum longiligulare polysaccharides 1- PLGA nanoparticle and its immune enhancement ability on RAW264.7 cells [J]. International Immunopharmacology, 2021, 99, 108053.

10. Xin Yang, Shiwei Zhou, Hong Li, Jiangwen An, Chengheng Li, Ruigang Zhou, Ling Teng, Yongjian Zhu, Suya Liao, Yuhui Yang, Huricha Chen, Yun Chen*. Structural characterization of Alpiniae oxyphyllae fructus polysaccharide 2 and its activation effects on RAW264.7 macrophages [J]. International Immunopharmacology, 2021, 97, 107708.

11. Yun Chen*, Qiyuan Luo, Shanman Li, Chengheng Li, Suya Liao, Xin Yang, Ruigang Zhou, Yongjian Zhu, Ling Teng, Huricha Chen, Yuhui Yang**. Antiviral activity against porcine epidemic diarrhea virus of Pogostemon cablin polysaccharide [J]. Journal of Ethnopharmacology, 2020, 259, 113009.

12. Xin Yang, Yuhui Yang, Huricha Chen, Teng Xu, Chengheng Li, Ruigang Zhou, Linglin Gao, Mengmeng Han, Xiaotao He, Yun Chen*. Extraction, isolation, immunoregulatory activity, and characterization of Alpiniae oxyphyllae fructus polysaccharides [J]. International Journal of Biological Macromolecules, 2020, 155, 927-937.

13. Yun Chen, Ruigang Zhou, Lixing He, Fengyang Wang, Xin Yang, Ling Teng, Chengheng Li, Suya Liao, Yongjian Zhu, Yuhui Yang, Huricha Chen*. Okra polysaccharide-2 plays a vital role on the activation of RAW264.7 cells by TLR2/4-mediated signal transduction pathways [J]. International Immunopharmacology, 2020, 86, 106708.

14. Yun Chen, Fangke Yao, Ke Ming, Jintong Shi, Ling Zeng, Deyun Wang, Yi Wu, Yuanliang Hu, Jiaguo Liu*. Assessment of the Effect of Baicalin on Duck Virus Hepatitis [J]. Current Molecular Medicine, 2019, 19, 376-386.

15. Yun Chen, Yuhui Yang, Wenjuan Yuan, Zhaohui Wang, Ke Ming, Ling Zeng, Jiaguo Liu*. Effects of Bush Sophora Root polysaccharide and its sulfate on DHAV-1 replication [J]. Carbohydrate Polymers, 2018, 197, 508-514.

16. Yun Chen, Wenjuan Yuan, Yuhui Yang, Fangke Yao, Ke Ming, Jiaguo Liu*. Inhibition mechanisms of baicalin and its phospholipid complex against DHAV-1 replication [J]. Poultry Science, 2018, 97: 3816-3825.

17. Yun Chen, Yuhui Yang, Fengyang Wang, Xin Yang, Fangke Yao, Ke Ming, Wenjuan Yuan, Ling Zeng, Jiaguo Liu*. Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1 [J]. Poultry Science, 2018, 97, 2722-2732.

18. Yun Chen, Ling Zeng, Yu Lu, Yulan Yang, Meiyun Xu, Yixuan Wang, Jiaguo Liu*. Treatment effect of a flavonoid prescription on duck virus hepatitis by its hepatoprotective and antioxidative ability. Pharmaceutical Biology [J], 2017, 55, 198-205.

19. Yun Chen, Ling Zeng, Jingjing Yang, Yixuan Wang, Fangke Yao, Yi Wu, Deyun Wang, Yuanliang Hu, Jiaguo Liu*. Anti-DHAV-1 reproduction and immuno-regulatory effects of a flavonoid prescription on duck virus hepatitis [J]. Pharmaceutical Biology, 2017, 55, 1545-1552.

20. Yun Chen, Fangke Yao, Ke Ming, Deyun Wang, Yuanliang Hu, Jiaguo Liu*. Polysaccharides from Traditional Chinese Medicines: Extraction, Purification, Modification, and Biological Activity [J]. Molecules, 2016, 21, 1705.

21. Yun Chen, Meiyun Song, Yixuan Wang, Wen Xiong, Ling Zeng, Shuaibing Zhang, Meiyun Xu, Hongxu Du, Jiaguo Liu*, Deyun Wang, Yi Wu, Yuanliang Hu. The anti-DHAV activities of Astragalus polysaccharide and its sulfate compared with those of BSRPS and its sulfate [J]. Carbohydrate Polymers, 2015, 117, 339-345.

22. Yun Chen, Ling Zeng, Wen Xiong, Meiyun Song, Hongxu Du, Yixuan Wang, Ke Ming, Yi Wu, Deyun Wang, Yuanliang Hu, Jiaguo Liu*. Anti-duck virus hepatitis mechanisms of Bush Sophora Root polysaccharide and its sulfate verified by intervention experiments [J]. Virus Research, 2015, 204, 58-67.

23. Yun Chen, Yi Wu, Luanting Xian, Meiyun Song, Ling Zeng, Wen Xiong, Jiaguo Liu*, Weidong Sun, Deyun Wang, Yuanliang Hu. Effects of Bush Sophora Root polysaccharide and its sulfate on immuno-enhancing of the therapeutic DVH [J]. International Journal of Biological Macromolecules, 2015, 80, 217-224.

24. Yun Chen, Wen Xiong, Ling Zeng, Deyun Wang, Jiaguo Liu*, Yi Wu, Yuanliang Hu. Comparison of Bush Sophora Root polysaccharide and its sulfate’s anti-duck hepatitis A virus activity and mechanism [J]. Carbohydrate Polymers, 2014, 102, 333-340.

25. Yun Chen, Wen Xiong, Ling Zeng, Yu Wang, Shuaibing Zhang, Meiyun Xu, Meiyun Song, Yixuan Wang, Hongxu Du, Jiaguo Liu*, Deyun Wang, Yi Wu, Yuanliang Hu. Bush Sophora Root polysaccharide and its sulfate can scavenge free radicals resulted from duck virus hepatitis [J]. International Journal of Biological Macromolecules, 2014, 66, 186-193.

26. 陈云，曾玲，熊文，张玲，张清，王德云，刘家国. 山豆根多糖及其硫酸酯体外抗DHV-1感染细胞作用的比较[J]. 南京农业大学学报，2014，37，117-122.

27. 朱永健，那威，杨雨辉，胡日查，杨鑫，李承姮，周瑞刚，韩蒙蒙，陈云*. 不同南药多糖对鸡传染性法氏囊病毒VP2蛋白免疫原性的影响[J]. 黑龙江畜牧兽医，2020，（18），119-123.

获奖及荣誉称号：

2023年，海南省D类高层次人才

团队合影：