畜禽替抗饲料添加剂研发及抗病营养关键调控团队-张海文

团队名称：畜禽替抗饲料添加剂研发及抗病营养关键调控技术示范团队

所属协同创新中心：南繁与热带高效农业协同创新中心

团队负责人：

张海文，海南省E类人才，海南省科协青年托举人才，海南省三区科技人才，省级科技特派员。主要研究方向为天然饲用抗生素替代品及功能性饲料添加剂。先后主持国家自然科学基金项目、海南省高层次人才项目、海南省科协青年创新人才项目等各级项目7项。出版专（编）著1部，参编书籍3部，发表学术论文60余篇，部分研究成果发表在《International Journal of Biological Macromolecules》《Poultry Science》《Journal of Immunology》《Phytomedicine》《Journal of Agricultural and Food Chemistry》《Food & Function》《Molecular Pharmaceutics》《International Immunopharmacology》《Frontiers in Microbiology》《Animals》《Veterinary Immunology and Immunopathology》《Peptides》《Scientific Reports》等国际期刊。获得海南大学优秀班主任称号，获得三区科技人才基层服务工作年度考核优秀评价。

团队研究方向：

1. 具有替代抗生素功能的畜禽饲料添加剂研发；

2. 通过营养手段调控畜禽肠道先天免疫功能；

3. 植物天然活性成分提取工艺研究与构效分析。

团队成员：

1. 谭振，博士，讲师；

2. 石惠宇，博士，讲师。

团队代表性成果：

1. 张海文, 管庆丰著,《动物营养与免疫概论》, 中国农业科学出版社, 2018, ISBN: 9787511635983.

2. Qin Xinyun^#; Nong Keyi^#; Liu Zhineng; Fang Xin; Zhang Bin; Chen Wanyan; Wang Zihan; Wu Yijia; Shi Huiyu; Wang Xuemei; Zhang Haiwen^*; Regulation of the intestinal flora using polysaccharides from Callicarpa nudiflora Hook to alleviate ulcerative colitis and the molecular mechanisms involved, International Journal of Biological Macromolecules, 2023, 258(Pt 1): 128887.（中科院1区，TOP期刊）

3. Fang Xin; Nong Keyi; Qin Xinyun; Liu Zhineng; Gao Feng; Jing Yuanli; Fan Haokai; Wang Zihan; Wang Xuemei; Zhang Haiwen^*; Effect of purple sweet potato-derived anthocyanins on heat stress response in Wenchang chickens and preliminary mechanism study, Poultry Science, 2023, 102(9): 102861. （中科院1区，TOP期刊）

4. Nong Keyi; Qin Xinyun; Liu Zhineng; Wang Zihan; Wu Yijia; Zhang Bin; Chen Wanyan; Fang Xin; Liu Youming; Wang Xuemei; Zhang Haiwen^*; Potential effects and mechanism of flavonoids extract of Callicarpa nudiflora Hook on DSS-induced colitis in mice, Phytomedicine, 2024, 128(3): 155523. （中科院1区，TOP期刊）

5. Liu Zhineng^#; Qin Xinyun^#; Nong Keyi; Fang Xin; Zhang Bin; Chen Wanyan; Wang Zihan; Wu Yijia; Shi Huiyu; Wang Xuemei; Zhang Haiwen^*; Oral administration of LfcinB alleviates DSS-induced colitis by improving the intestinal barrier and microbiota, Food & Function, 2024, 15(4): 2038 – 2051.（中科院1区，TOP期刊）

6. Nong Keyi^#; Liu Zhineng^#; Qin Xinyun; Chen Wanyan; Zhang Bin; Wu Yijia; Wang Zihan; Fang Xin; Liu Youming; Wang Xuemei; Sh Huiyui; Zhang Haiwen^*; Effect of the Pseudopleuronectes americanus-derived Pleurocidin on DSS-induced Ulcerative colitis in mice and its preliminary molecular mechanisms, International Immunopharmacology, 2024, 130: 111757. （中科院2区，TOP期刊）

7. Chen Tao; Hu Shihui; Zhang Haiwen^*; Guan Qingfeng; Yang Yuhui; Wang Xuemei^*; Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model, Food & Function, 2017, 8(2): 659-669.（中科院1区，TOP期刊）

8. Zhang Haiwen^*; Hua Rui; Zhang Bingxi; Guan Qingfeng; Zeng Jifeng; Wang Xuemei; Wang Beibei; Oral administration of bovine lactoferrin derived Lactoferricin (Lfcin) B could attenuate enterohemorrhagic Escherichia coli O157:H7 induced intestinal disease through improving intestinal barrier function and microbiota, Journal of Agricultural and Food Chemistry, 2019, 67(14): 3932-3945.（中科院1区，TOP期刊）

9. Qin Xinyun; Liu Zhineng; Nong Keyi; Fang Xin; Chen Wanyan; Zhang Bin; Wu Yijia; Wang Zihan; Shi Huiyu; Wang Xuemei; Zhang Haiwen^*; Porcine-derived antimicrobial peptide PR39 alleviates DSS-induced colitis via the NF-kappaB/MAPK pathway, International Immunopharmacology, 2024, 127: 111385. （中科院2区，TOP期刊）

10. Zhang Haiwen; Huang Liangmin; Hu Shihui; Qin Xinyun; Wang Xuemei^*; Moringa oleifera Leaf Powder as New Source of Protein-Based Feedstuff Improves Growth Performance and Cecal Microbial Diversity of Broiler Chicken, Animals (Basel), 2023, 13(6): 1104.

11. Nong Keyi^#; Liu Youming^#; Fang Xin; Qin Xinyun; Liu Zhineng; Zhang Haiwen^*; Effects of the Vitamin D3 on Alleviating the Oxidative Stress Induced by Diquat in Wenchang Chickens, Animals (Basel), 2023, 13(4): 711.

12. Fang Xin^#; Nong Keyi^#; Wang Zihan; Jing Yuanli; Gao Feng; Zeng Qiuyu; Wang Xuemei; Zhang Haiwen^*; Human cathelicidin LL-37 exerts amelioration effects against EHEC O157:H7 infection regarding inflammation, enteric dysbacteriosis, and impairment of gut barrier function, Peptides, 2023, 159: 170903.

13. Zhang Haiwen; Hua Rui; Zhang Bingxi; Guan Qingfeng; Wang Beibei^*; Zeng Jifeng; Wang Xuemei; Wu Kebang^*; Cathelicidin-derived PR-39 protects enterohemorrhagic Escherichia coli O157:H7 challenged mice by improving epithelial function and balancing the microbiota in the intestine, Scientific Reports, 2019, 9(1): 9456.

14. Zhang Haiwen^#; Xia Xi^#; Han Feifei; Jiang Qin; Rong Yili; Song Deguang; Wang Yizhen^*; Cathelicidin-BF, a novel antimicrobial peptide from Bungarus fasciatus, attenuates disease in a dextran sulfate sodium model of colitis, Molecular Pharmaceutics, 2015, 12(5): 1648-1661.

15. Zhang Haiwen^*; Liu Youming; Fang Xin; Gu Lihong; Luo Caiwei; Chen Lu; Wang qian; Vitamin D3 Protects Mice from Diquat-Induced Oxidative Stress through the NF-kappaB/Nrf2/HO-1 Signaling Pathway, Oxidative medicine and cellular longevity, 2021, 2021: 6776956.

16. Zhang Haiwen; Hua Rui; Zhang Bingxi; Zhang Xiaomeng; Yang Hui; Zhou Xihong ^*; Serine alleviates dextran sulfate sodium-induced colitis and regulates the gut microbiota in mice, Frontiers in microbiology, 2018, 9: 3062.

17. Zhang Haiwen; Zhang Bingxi; Zhang Xiaomeng; Wang Xuemei; Wu Kebang; Qingfeng Guan^*; Effects of cathelicidin-derived peptide from reptiles on lipopolysaccharide-induced intestinal inflammation in weaned piglets, Veterinary Immunology and Immunopathology, 2017, 192: 41-53.

18. Han Feifei^#; Zhang Haiwen^#; Xia Xi; Xiong Haitao; Song Deguang; Zong Xin; Wang Yizhen^*; Porcine beta defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis, Journal of Immunology, 2015, 194(4): 1882-1893.

团队合影：