闻晓波

男，博士，中共党员；教授；博士/硕士研究生导师；

海南省拔尖人才；海南省地方猪产业技术体系岗位科学家

邮箱：xiaobo_wen@hainanu.edu.cn

通讯地址：海南省海口市美兰区人民大道58号，邮政编码：570228

研究领域

动物传染病的预防与控制

教育背景

2003年9月 - 2006年6月 中国农业科学院哈尔滨兽医研究所 预防兽医专业 博士

2000年9月 - 2003年6月 黑龙江八一农垦大学 预防兽医专业 硕士

1996年9月 - 2000年6月 黑龙江八一农垦大学 动物医学专业 学士

工作经历

2006年7月 - 2008年8月 黑龙江八一农垦大学动物科技学院 讲师

2008年9月 - 2008年12月 黑龙江八一农垦大学动物科技学院 副教授

2009年1月 - 2012年6月 美国国立卫生研究院（NIH） 博士后

2012年7月 - 2017年9月 黑龙江八一农垦大学动物科技学院 副教授

2017年9月 - 2019年10月 黑龙江八一农垦大学动物科技学院 教授

2019年11月 - 2023年8月 海南大学动物科技学院 教授

2023年9月 - 至今 海南大学热带农林学院 教授

讲授课程：

本科：兽医传染病学、兽医微生物学、兽医生物制品学、兽医学概论

研究生：兽医临床病例分析与研讨专题、文献解析专题、兽医生物制品学专题

科研项目

1. 国家自然科学地区基金项目，轮状病毒NSP2、NSP5决定病毒质装配及RNA包装的关键互作位点定位及机制研究、2024/1-2027/12、32万元、在研、主持。

2. 海南省农业农村厅，海南省地方猪现代农业产业技术体系专项，2022/1-2025/12、96万元。

3. 海南大学科研启动项目，猪塞内卡病毒调控IFN信号转导通路及病毒致弱机制研究、2020/5-2025/5、100万元，在研，主持。

4. 海南省自然科学基金项目，猪塞内卡病毒3C蛋白调控IFN信号转导通路的关键结构域及其作用机制、2020/12-2023/12、7万元，已结题，主持。

5. 国家自然科学基金青年项目，牛UK株轮状病毒拮抗Ⅰ型IFN信号转导通路机制的研究、2013/1-2015/12、24万元、已结题、主持。

6. 黑龙江省科学基金面上项目，异源宿主细胞内牛轮状病毒NSP1蛋白调控IFN免疫应答机制、2015/7-2018/7、10万元、已结题、主持。

7. 博士后研究人员落户黑龙江科研启动资助项目，Caco-2细胞网格蛋白表达对轮状病毒侵入的影响、2014/1-2016/12、5万元、已结题、主持。

发表论文

[1] Zhao S M, Cui H Q, Hu Z R, Du L, Ran X H, Wen X B*. Senecavirus A Enhances Its Adaptive Evolution via Synonymous Codon Bias Evolution [J]. Viruses-Basel, 2022, 14(5): 1055.

[2] Zhang X, Cui K, Wen X, Li L, Yu X, Li B, Lin H, He H, Wang F. The Association between Gut Microbiome Diversity and Composition and Heat Tolerance in Cattle [J]. Microorganisms, 2022, 10(8): 1672.

[3] Lv Q, Ran X, Qiu H, Zhao S, Hu Z, Wang J, Ni H, Wen X*. Seroprevalence of pullorum disease in chicken across mainland China from 1982 to 2020: A systematic review and meta-analysis [J]. Res Vet Sci, 2022, 152: 156-66.

[4] Yang Y, Teng Z, Lu Y, Luo X, Mu S, Ru J, Zhao X, Guo H, Ran X, Wen X*, Sun S*. Enhanced immunogenicity of foot and mouth disease DNA vaccine delivered by PLGA nanoparticles combined with cytokine adjuvants [J]. Res Vet Sci, 2021, 136: 89-96.

[5] Gong Q L, Chen Y, Tian T, Wen X, Li D, Song Y H, Wang Q, Du R, Zhang X X. Prevalence of bovine tuberculosis in dairy cattle in China during 2010-2019: A systematic review and meta-analysis [J]. PLoS Negl Trop Dis, 2021, 15(6): e0009502.

[6] Dong H, Lu Y L, Zhang Y, Mu S Y, Wang N, Du P, Zhi X Y, Wen X B, Wang X X, Sun S Q, Zhang Y M, Guo H C. A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity [J]. J Virol, 2021, 95(16): e0017721.

[7] Wen X, Tong X, Wang M, Wang J, Ni H, Ran X. Protective immunity following vaccination with a recombinant multiple-epitope protein of bovine herpesvirus type I in a rabbit model [J]. Appl Microbiol Biotechnol, 2020, 104: 3011-23.

[8] Ni H, Jia X X, Wang J, Ran X, Wen X*. Mapping a highly conserved linear neutralizing epitope at the N-terminus of the gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. Microb Pathog, 2020, 138: 103815.

[9] Mu S, Abdullah S W, Zhang Y, Han S, Guo H, Li M, Dong H, Xu J, Teng Z, Wen X, Sun S*. Development of a novel SYBR green I-based quantitative RT-PCR assay for Senecavirus A detection in clinical samples of pigs [J]. Mol Cell Probes, 2020, 53: 101643.

[10] Lu Y, Dong H, Li J, Li L, Wang M, Liu H, Teng Z, Zhang Y, Jin Y, Guo H, Yang Y, Wen X*, Sun S*. Enhanced Protective Immune Response of Foot-and-mouth Disease Vaccine through DNA-loaded Virus-like Particles [J]. Microb Pathog, 2020, 143: 104130.

[11] Wang X, Bi Y, Ran X, Tong X, Ni H, Wen X*. Mapping a highly conserved linear neutralizing epitope on gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. J Vet Med Sci, 2019, 81(5): 780-6.

[12] Ran X, Yang Z, Bai M, Zhang Y, Wen X, Guo H, Sun S. Development and validation of a competitive ELISA based on bacterium-original virus-like particles of serotype O foot-and-mouth disease virus for detecting serum antibodies [J]. Appl Microbiol Biotechnol, 2019, 103(7): 3015-24.

[13] Ran X, Meng X Z, Geng H L, Chang C, Chen X, Wen X*, Ni H*. Generation of porcine Pasteurella multocida ghost vaccine and examination of its immunogenicity against virulent challenge in mice [J]. Microb Pathog, 2019, 132: 208-14.

[14] Ran X, Cheng J, Wang M, Chen X, Wang H, Ge Y, Ni H, Zhang X X*, Wen X*. Brucellosis seroprevalence in dairy cattle in China during 2008-2018: A systematic review and meta-analysis [J]. Acta Trop, 2019, 189: 117-23.

[15] Ran X, Chen X, Wang S, Chang C, Wen X, Zhai J, Ni H. Preparation of porcine enterotoxigenic Escherichia coli (ETEC) ghosts and immunogenic analysis in a mouse model [J]. Microb Pathog, 2019, 126: 224-30.

[16] Ran X, Chen X, Ma L, Wen X, Zhai J, Wang M, Tong X, Hou G, Ni H. A systematic review and meta-analysis of the epidemiology of bovine viral diarrhea virus (BVDV) infection in dairy cattle in China [J]. Acta Trop, 2019, 190: 296-303.

[17] Ran X, Yang Z, Shao G, Wen X, Liu S, Ni H. Avian Salmonella enteritidis serovar Enteritidis with ClpP deletion is attenuated and highly immunogenic in chickens [J]. Turkish Journal of Veterinary and Animal Sciences, 2018, 42(4): 269-76.

[18] Ran X, Chen X, Wang M, Cheng J, Ni H, Zhang X X*, Wen X*. Brucellosis seroprevalence in ovine and caprine flocks in China during 2000-2018: a systematic review and meta-analysis [J]. BMC Vet Res, 2018, 14(1): 393.

[19] Wen X, Sun J, Zhang Y, Cao S, Ran X, Ni H. Identification and genetic characterization of bovine parainfluenzavirus type 3 genotype c strain isolated from cattle in western China [J]. Turkish Journal of Veterinary and Animal Sciences, 2017, 41: 180-6.

[20] Wen X B, Jiang H T, Zhang Y L, Lang X Y, Liu J, Ni H B. Rapid and Sensitive Diagnosis of Cattle Anaplasmosis by Loop-Mediated Isothermal Amplification (LAMP) [J]. Pakistan Veterinary Journal, 2016, 36(2): 174-8.

[21] Wen X, Wei X, Ran X*, Ni H, Cao S, Zhang Y. Immunogenicity of porcine P[6], P[7]-specific truncated VP8* rotavirus subunit vaccines with a tetanus toxoid universal T cell epitope [J]. Vaccine, 2015, 33(36): 4533-9.

[22] Wen X, Cao D, Jones R W, Hoshino Y, Yuan L. Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic [J]. Human vaccines & immunotherapeutics, 2015, 11(10): 2483-9.

[23] Ma Y, Wen X, Hoshino Y, Yuan L*. Cloning and nucleotide sequence analyses of 11 genome segments of two American and one British equine rotavirus strains [J]. Veterinary microbiology, 2015, 176(1-2): 172-8.

[24] Wen X, Wen K, Cao D, Li G, Jones R W, Li J, Szu S, Hoshino Y, Yuan L*. Inclusion of a universal tetanus toxoid CD4(+) T cell epitope P2 significantly enhanced the immunogenicity of recombinant rotavirus DeltaVP8* subunit parenteral vaccines [J]. Vaccine, 2014, 32(35): 4420-7.

[25] Wen X, Cao D, Jones R W, Li J, Szu S, Hoshino Y*. Construction and characterization of human rotavirus recombinant VP8* subunit parenteral vaccine candidates [J]. Vaccine, 2012, 30(43): 6121-6.

[26] Long-Croal L M, Wen X, Ostlund E N, Hoshino Y*. Concentration of acrylamide in a polyacrylamide gel affects VP4 gene coding assignment of group A equine rotavirus strains with P[12] specificity [J]. Virology journal, 2010, 7: 136.